For γ-oryzanol, various kinds of pharmacodynamic and applied clinical effects including growing effect 2) are reported and especially the following therapeutic effects are known on various symptoms caused by cephalic or cervical injuries (whiplash injury) 3), autonomic imbalance 4) 5), menopausal syndrome 6) 7), its accompanied malaises 8-11), amenia, hypoovarianism 12) and stress ulcers 13) 14). In addition, γ-oryzanol has such functions as circulation effect 15) 16), sebum secretomotor effect 17) and ultraviolet absorbing effect 18) derived from ferulic acid. Moreover, for anti-oxidant action, in comparison with tocopherol, γ-oryzanol is reported to be much superior in heat resistance 15) and it is also said that the interaction between them further improves the anti-oxidant action. From these facts, γ-oryzanol seems to be very useful 19). It also provides extremely high safety 20) because any special side effect is found in spite of showing many hormonelike effects. Its applications include the utilization to various drug material making use of its multiple medicinal effects and, in cosmetic area, the application to creams and sunscreens 21￣24) exploiting its skin age resistor function 15) and ultraviolet absorbing effect. It is listed as "oxidation inhibitor" in the "Food Additive List" and, for this usage, there are a lot of patents 25-39). Although γ-oryzanol has a steroid hormonelike effect, it is consistently safe and is mixed in the feed for racehorses as an additive because it is not an inhibited agent. Currently, some esters including cycloaltenylpherrate have begun to be produced and studies on their respective functions are being performed. ■Ref 1) Endo et al.,Journal of the Japan Oil Chemists' Society,7,6 (1968) 2) T.Tsuchiya et al.,Kogyo Kagaku Zasshi,57,526 (1954) 3) R.Hiyama et al.,Pharmacometrics,12,(3),363 (1967) 4) Kusuda et al.,Obstetrical and Gynecological Practice,14,(7),587 (1965) 5) S.Tsutsui et al.,Clinical Evaluation,13,1,137 (1985) 6) Murase,Obstetrical and Gynecological Practice,12,(2),147 (1963) 7) Okawa et al.,World of Obstetrics and Gynecology,17,2,65 (1965) 8) S.Takeuchi et al.,World of Obstetrics and Gynecology,33,11,87 (1981) 9) S.Kishi et al,Journal of New Remedies & Clinics,25,12,33 (1976) 10) T.Takemoto et al.,Journal of Adult Diseases,7,11,133 (1977) 11) T.Yamaguchi et al.,Journal of New Remedies & Clinics,23,7,3 (1974) 12) Watanabe et al.,Obstetrical and Gynecological Practice,14,959 (1965) 13) Itatani et al.,,Folia pharmacol. japon,72,475 (1976) 14) Itatani et al.,Folia pharmacol. japon.,72,1001 (1976) 15) Kamimura et al.,Japanese Journal of Clinical Dermatology,17,(4),369 (1963) 16) M.Kobayashi,Journal of Japanese Cosmetic Science Society,8,1,41 (1984) 17) M.Oshida､Research on Home Medicines,No.4,34 (1985) 18) T.Fukushi et al.,Hokkaido Kosho Eisei Kenkyujo Hokoku,16,115 (1966) 19) Nomura,Journal of New Remedies & Clinics,29,5,158 (1980) 20) Hanesato et al.,Clinical Report,8,(11),3417 (1974) 21) M.Mitani,Jpn.Tokkyo Koho 1969-58003 22) T.Sato,Jpn.Kokai Tokkyo Koho 1978-64208 23) Nomura et al.,Jpn.Kokai Tokkyo Koho 1980-55108 24) K.Ishibashi,Jpn.Kokai Tokkyo Koho 1996-188521 25) Tsuchiya et al.,Jpn.Kokai Tokkyo Koho 1983-150600 26) Tsuchiya et al.,Jpn.Kokai Tokkyo Koho 1982-149248 27) Asano et al.,Jpn.Kokai Tokkyo Koho 1976-56441 28) Asano et al.,Jpn.Kokai Tokkyo Koho 1975-160262 29) G.Kimura,Jpn.Kokai Tokkyo Koho 1988-14797 30) G.Kimura,Jpn.Kokai Tokkyo Koho 1986-14796 31) Y.Kimura,Jpn.Kokai Tokkyo Koho 1980-162740 32) Tagashira et al.,Jpn.Kokai Tokkyo Koho 1987-277326 33) Tagashira et al,Jpn.Kokai Tokkyo Koho 1986-106512 34) S.Ito､Jpn.Kokai Tokkyo Koho 1985-130598 35) J.Imadu et al.,Jpn.Kokai Tokkyo Koho 1975-66746 36) K.Kobayashi et al.,Jpn.Kokai Tokkyo Koho 1986-248407 37) T.Inagaki.,Jpn.Kokai Tokkyo Koho 1986-40298 38) T.Inagaki et al.,Jpn.Kokai Tokkyo Koho 1985-248611 39) Goto et al.,Jpn.Kokai Tokkyo Koho 1986-194022 *For further information please contact with our trading division